In this thesis, we have successfully developed routes to engineer the electronic properties of graphene, either by controllable strain or by double moiré superlattices. A new platform that combines in situ strain tuning and transport experiments was developed. With this platform, various strain effects were studied in different transport measurements at low temperatures. In addition, we discovered a new generation of moiré superlattices in doubly aligned hBN/graphene/hBN heterostructures.