YAP and TAZ play a fundamental role in oncogenic transformation, organ development, stem cell amplification and regeneration during tissue damage. YAP and TAZ elicit their biological functions through the transcriptional regulation of downstream genes and effector pathways. We found that autophagy is modulated by YAP and TAZ. Given the central role of YAP and TAZ in mechanotransduction, we also confirmed that the mechanical cues control autophagy through YAP/TAZ. Importantly, autophagy control is integral to YAP/TAZ biology.