When a child is diagnosed with cancer, it has a major impact on both the child and the family. Cancer treatment causes a certain level of medical traumatic stress, and the family is disrupted. Coping with this stress is important to reduce the psychosocial impact of the disease and its treatment. Advances in technology have offered new opportunities, especially interactive tools, for psychosocial interventions for children and their families during treatment, both at the hospital and at home. This thesis is about several interactive tools that we developed for this purpose and scientifically evaluated in five prospective clinical studies. In the first part of this thesis, we explored the introduction of a social robot (Hero) into pediatric oncology care. We used multiple methods, including logbooks, observations, questionnaires and interviews to examine: (1) The feasibility of using a social robot in the pediatric oncology setting, (2) the experiences of children, families and health care providers with the social robot, and (3) the potential effectiveness of the social robot. In the second part of this thesis, we explored the use of two interactive tools (AscoltaMe and Mr.V) for families with a child with cancer at home. We used multiple methods, including machine data, family diaries, pictures and videos, questionnaires and interviews to examine: (1) The feasibility and acceptability of families with a child with cancer of using the interactive tools at home, (2) the experiences of children and families with the interactive tools, and (3) the potential effectiveness of the interactive tools.