The tanning industry of Bangladesh has been facing an emerging threat to international leather market for not achieving third party compliance certification. Moreover, losing buyers, a mentionable decrease in workorders, and losing reputation in international leather domain are being considered a matter of concern for not being able to establish a safe chemical management system in Bangladesh tanning industry. Numerous factors are being thought liable for chemical management deviations. This thesis paper traced out the factors by performing qualitative and empirical data analysis. The qualitative data has been gathered from the secondary data sources and the quantitative analysis has been accomplished by conducting in person survey procedure among 125 employees from six different tanneries in BSCIC Tannery Industrial Estate, Hemayetpur, Savar, Dhaka, Bangladesh. The quantitative analysis has been performed using IBM SPSS statistical program v-29. Factor analysis has been conducted to extract the factors that contribute to chemical management deviations in tannery. The results depicted four key factors i.e., chemical related knowledge on storage and unloading, Employers attitude towards chemical effluent disposal and chemical dosing, factual complications to achieve third party certification, and chemical training and safety concern that are playing as key element for chemical management deviations in Bangladesh tanning industry. To tackle these obstacles, this thesis paper suggested some interventions in relation to chemical related Laws, Rules, Standards, Guidelines, Policies, and best practices that are being followed in global tanning industry. Moreover, opinion from chemical experts acquired by online survey have also been included to improve the chemical management deviations. On top of that suggestions were considered in regards to strengthen the different stakeholders for establishing a safe chemical management system in tanning industry of Bangladesh. To attain the sustainable improvement in chemical management system of Bangladesh tanning industry, a cumulative effort from government, employers, workers, and buyers and brands become an immense need.