Clinical aspects of non-severe hemophilia: Focus on bleeding, joint and treatment outcomes - PhDData

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Clinical aspects of non-severe hemophilia: Focus on bleeding, joint and treatment outcomes

The thesis was published by Kloosterman, F.R., in January 2023, University of Amsterdam.

Abstract:

Hemophilia A and B are rare inherited bleeding disorders, caused by mutations in the F8 or F9 gene on the X-chromosome leading to a deficiency of coagulation factor VIII (FVIII) or coagulation factor IX (FIX), respectively. As a result, persons with decreased coagulation FVIII/IX levels have an increased bleeding tendency. Classification of disease severity is based on the endogenous FVIII/IX level, ranging from severe (FVIII/IX



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