The main objective of AngioCT is to obtain adequate opacification of the vascular compartment of interest, synchronized with the CT acquisition. Contrast medium (CM) distribution and opacification of the vascular territory of interest are influenced by different factors: patient-related factors, CM-related factors and MDCT scanner-related factors. In Veterinary Medicine, many aspects regarding the influence of different factors on contrast enhancement remain underdeveloped. Therefore, the aim of our systematic review is to evaluate these factors and their influence on contrast enhancement. The systematic literature review followed the PRISMA (Preferred Reporting Items for Systematic Reviews, 2020) flowchart. Research was conducted on bibliographic online databases (WebofScience, PubMed, Scopus, CABAbstract) using different key words. After screening of the identified studies, 20 studies were included in final corpus of the systematic review. The amount of abdominal adipose tissue on enhancement represents a very interesting and little-considered factor in daily clinical practice, which makes it possible to reduce the dose of CM to the patient and the related adverse effects or toxicity. Regarding CM injection, the speed of transport of iodine seem to be a more influencing factor, rather than the duration of injection, especially at the arterial and hepatic level, with possible clinical implications of great relevance. When a slow scanner or a long scan duration is available, it may be advisable to use a fixed CM injection duration for the acquisition of the different vascular phases. On the contrary, with faster scanners, the bolus tracking technique guarantees a higher quality between the vascular phases. Finally, a saline flush at the end of the administration of CM permits to increase arterial enhancement and reduce the dose of CM to the patient. This systematic review highlights some factors and can form the basis for further study regarding factors influencing enhancement on angioCT in small animals.