In this thesis hypergranulation tissue in both the breast after breast implant surgery, as well as in the skin (scar formation) is explored. The histological composition of capsular contracture after breast implant surgery and the role of silicone in this tissue is investigated in multiple papers. Furthermore, the classification used to grade capsular contracture complaints is evaluated. In the second part, the role the systemic immune system has in hypertrophic scarring is examined, and how to use these differences to enable prognostic tools.