Summary This thesis describes clinico- and histopathological prognosticators as well as outcome in malignant salivary gland carcinomas of the head and neck with an emphasis on three predominant tumor types: Adenoid cystic carcinoma (ACC), mucoepidermoid carcinoma (MEC) and acinic cell carcinoma (AciCC). The results presented were gathered through retrospective analysis of patient data from the Amsterdam University Medical Centres (Amsterdam UMC) Vrije Universiteit Amsterdam. In the study regarding AciCC, patient data from both the Amsterdam UMC and the Netherlands Cancer Institute (NKI) were used.