Healthcare services have been evolving continuously owing to new demands caused by demographic and lifestyle changes. The advancements in information and communication technology (ICT) have propelled the development of new healthcare systems that can fulfil these demands. One of the key developments in this field is in the form of telemedicine systems, which aims to reliably deliver remote healthcare to patients through information exchange across distances. This research is conducted in the context of ambulatory patient treatment guidance where a patient can receive remote treatment that is compliant with the current care-plan, without the presence of his/her doctor, with the aid of a telemedicine system. In order to provide treatment guidance that complies with healthcare procedures, telemedicine systems may apply clinical guidelines. Additionally, the ICT of these telemedicine systems enables the acquisition of patient clinical data. Hence, the clinical guidelines, in combination with ubiquitously acquired patient clinical data, may result in a personalized treatment guidance that will provide the necessary remote treatment to the patient without the need of a practitioner.