Stable antifungal semi-solid formulations were modelled. Bigels with ciclopirox olamine and terbinafine hydrochloride were modelled for the first time. Biopharmaceutical studies have been carried out and the obtained results prove the influence of active substances insertion place for the antifungal substance release from semi-solid formulation. Using biopharmaceutical investigation, the influence of the oleogel quantity in formulation for the released amount of active substance was confirmed. Rheological methods were selected and applied to evaluate the quality of semi-solid formulations. According to the results of rheological studies, the influence of thymol for rheological properties and stability were established. The obtained results of rheological studies are informative in evaluating the quality of semi-solid formulations. Rheological tests were developed and used to evaluate the gelification temperature of gels and bigels. Patches with ciclopirox olamine and terbinafine hydrochloride were modelled and evaluated. The aim of the study. To model stable antifungal semisolid formulations and to evaluate their rheological and biopharmaceutical properties. The objectives of the study: 1. To select the appropriate vehicles for drug delivery to ensure the antifungal activity of formulated semisolid formulations. 2. To model different semisolid forms with antifungal substances and evaluate their quality. 3. To investigate the excipients influence on the rheological properties and stability. 4. To evaluate the influence of excipients and pharmaceutical forms on the release of the active substances. 5. To determine the antifungal activity of the experimental formulations.