Even though Zika virus (ZIKV) had already been discovered in 1947, because of the presumed mild and uncomplicated infection presentation in humans, limited research on ZIKV was carried out prior to the 2015-2016 outbreak in the Americas. Therefore, the emergence of ZIKV and its associated complications came as a surprise to many healthcare providers, scientists, and public-health workers worldwide. A better understanding of the pathogenicity of ZIKV is essential for the prevention of future ZIKV outbreaks and the prevention of ZIKV-associated complications and their possible treatment. In this thesis, we aim to study multiple facets of ZIKV, such as its epidemiology, the complications of a ZIKV infection and the possible interactions between ZIKV and other flaviviruses.