The aim of the present thesis was to investigate the implementation of the 2015 ESC guidelines for IE in The Netherlands (part I), and to investigate the value of a multidisciplinary approach in the management of IE and to provide possible alternative ways to sustain this approach safely, especially during the COVID-19 pandemic (part II). This thesis also provides normal PET/CT reference imaging findings and values after prosthetic valve (and ascending aortic prosthesis) implantation and explores the additional diagnostic value of PET/CT and cardiac CTA in the diagnosis of infective endocarditis in specific patient populations (part III and IV). In addition, it evaluates the current role of cardiac CTA in patients with IE, especially in the detection of coronary artery disease (part IV).