Within the retina, M端ller glial cells (MGCs) are central regulators of metabolic homeostasis during normal function and during pathogenic states. MGCs are major producers of Galectins (Gal) -1 and -3, carbohydrate-binding proteins which have been found to be key regulators of various cellular processes. This study aimed to investigate the potential roles of Gal-1 and -3 during inflammatory stimuli, as well as during models of retinal development and degeneration.
Treatment of MIO-M1 cells with the pro-inflammatory cytokine IL-1 resulted in significant upregulation of Gal-1 (p