Aims

A fractional flow reserve (FFR) value ≥ 0.90 after percutaneous coronary intervention (PCI) is associated with a reduced risk of adverse cardiovascular events. TARGET-FFR was an investigator-initiated, single centre, randomised controlled trial to determine the feasibility and efficacy of a post-PCI FFRguided optimisation strategy versus standard coronary angiography in achieving final post-PCI FFR values ≥ 0.90.

Methods and Results

After angiographically-guided PCI, patients were randomised 1:1 to receive a Physiology-guided Incremental Optimisation Strategy (PIOS) or a blinded coronary physiology assessment (control group). The primary outcome was the proportion of patients with a final post-PCI FFR ≥ 0.90. Final FFR ≤ 0.80 was a prioritised secondary outcome. 260 patients were randomised (131 to PIOS, 129 to control). 68.1% of patients had an initial post-PCI FFR